Interplay among regulators of multidrug resistance in Kluyveromyces lactis
نویسندگان
چکیده
منابع مشابه
Interplay among regulators of multidrug resistance in Kluyveromyces lactis.
The KlYAP1 and KlPDR1 genes encode two main transcriptional regulators involved in the control of multidrug resistance in Kluyveromyces lactis. Deletion of KlPDR1 or KlYAP1 genes in K. lactis generated strain hypersusceptible to diamide, benomyl, fluconazole and oligomycin. Overexpression of genes KlPDR1 or KlYAP1 from a multicopy plasmid in the Klpdr1Δ mutant strain increased the tolerance of ...
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The membrane fluidity of reduced-amphotericin B (AmB)-sensitivity Kluyveromyces lactis mutant strain is higher than that of the wild-type K. lactis strain. After culture of the K. lactis and K. lactis mutant cells in the presence of subinhibitory doses of AmB (10 and 125 mg/liter, respectively), the plasma membranes of both yeast strains also showed a higher fluidity than did those of control c...
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ژورنال
عنوان ژورنال: General physiology and biophysics
سال: 2011
ISSN: 1338-4325
DOI: 10.4149/gpb_2011_si1_77